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Published in

Oxford University Press, Nucleic Acids Research, 19(17), p. 7623-7630, 1989

DOI: 10.1093/nar/17.19.7623

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Polymers of random short oligonucleotides detect polymorphic loci in the human genome.

Journal article published in 1989 by Gilles Vergnaud ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Polymers of random 14 mer oligonucleotides are shown to detect discrete loci in the human genome. Eighteen different synthetic tandem repeats of random 14 base-pair units (STRs) have been generated and all of them turn out to detect polymorphic loci on southern blots of human DNA samples, presumably corresponding to a variable number of tandem repeats (VNTR). This finding suggests that minisatellites are a major component of the human genome and are strongly associated with the generation of genetic variability. In addition, it should open new strategies to make new polymorphic probes available.