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Elsevier, Tetrahedron Letters, 5(54), p. 370-372, 2013

DOI: 10.1016/j.tetlet.2012.10.133

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Synthesis of lactams using enzyme-catalyzed aminolysis

Journal article published in 2013 by E. Stavila, K. Loos ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The formation of ε-caprolactam from 6-aminocaproic acid catalyzed by CALB (N435) is reported. Different lactam ring sizes can be prepared starting from 4-aminobutanoic acid, 5-aminovaleric acid, and 8-aminooctanoic acid. Experiments with mixtures of aminocarboxylic acids have shown that CALB prefers homocyclization of the individual aminocarboxylic acids.