Wiley, Journal of Labelled Compounds and Radiopharmaceuticals, 13(44), p. 881-888
DOI: 10.1002/jlcr.512
Full text: Unavailable
The synthesis of 15N-labelled nornicotine 2 and 15N-labelled nicotine 1 is described via the reductive aminocyclization of a 1,4-ketoaldehyde with a corresponding amine in the presence of sodium cyanoborohydride. Yields of 30% and 26%, respectively, were obtained from 3-bromopyridine. The 15N-label has been easily introduced from ammonium-15N-labelled chloride as an inexpensive label source. As far as we are aware, this is the first synthesis of 15N-labelled nicotine. Copyright © 2001 John Wiley & Sons, Ltd.