The present day Cyclades Plateau in Central Aegean Sea (Greece) is characterised by the presence of numerous small islands and an extended shelf. The interpretation of high-resolution seismic profiles reveals that the shelf has been subjected to successive stages of submergence and emergence due to the Quaternary relative sea level changes. This has resulted to shelf seabed erosion by sub-aerial conditions or palaeo-surfaces burial by thick deltaic/coastal sequences. Within this complicated habitat, it is very difficult for Palaeolithic human remains to be discovered due to their elimination by physical processes. On the basis of present study's bathymetric data set and applying the model developed by LAMBECK (1996), a detailed description of the palaeo-geography of Cyclades shelf since the Last Glacial Maximum (LGM) (ca. 20,000 B.P.) has been accomplished. In addition, a statistical analysis has shown a loss of the three-fourth of the initial surface area of the Plateau, lip to present time. The low-lying shelf areas, with an average slope of 1.58 degrees, perhaps provided appropriate conditions for sustaining human, animal and plant life. Therefore, parts of this area could present high geoarchaeological interest improving our knowledge in relation to human activities and associated environments during Uppermost Palaeolothic, Mesolithic and Neolithic.