Published in

Wiley, Advanced Synthesis & Catalysis, 16(354), p. 2921-2927, 2012

DOI: 10.1002/adsc.201200101

Links

Tools

Export citation

Search in Google Scholar

Asymmetric Intramolecular CH Insertion of α‐Diazoacetamides in Water by Dirhodium(II) Catalysts Derived from Natural Amino Acids

Journal article published in 2012 by Nuno R. Candeias ORCID, M. Teresa Duarte, Carolina Carias, Luis F. R. Gomes, Vânia André ORCID, M. Teresa Duarte ORCID, Pedro M. P. Gois ORCID, Carlos A. M. Afonso
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The asymmetric dirhodium(II)-catalyzed intramolecular CH insertion of α-diazo acetamides in water is described for the first time. The use of natural α-amino acids as chiral ligands allowed the preparation of novel dirhodium(II) homochiral complexes by a simple procedure consisting of the in situ ligand exchange starting from dirhodium tetraacetate. The catalytic system was further reused up to 7 cycles and β-lactams were obtained in good yields and enantiomeric excess.