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American Association for the Advancement of Science, Science, 6012(330), p. 1775-1787, 2010

DOI: 10.1126/science.1196914

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Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project

Journal article published in 2010 by Zhi John Lu, Eric L. Van Nostrand, Mark B. Gerstein, Gerstein Mb, Bradley I. Arshinoff, Lu Zj, Kevin Y. Yip, Van Nostrand El, Raymond K. Auerbach, Chao Cheng, Arshinoff Bi, Ashish Agarwal, Roger P. Alexander, Alexander Rp, Galt Barber and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

From Genome to Regulatory Networks For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used to help to produce a functional organism (see the Perspective by Blaxter ). In this vein, Gerstein et al. (p. 1775 ) summarize for the Caenorhabditis elegans genome, and The modENCODE Consortium (p. 1787 ) summarize for the Drosophila melanogaster genome, full transcriptome analyses over developmental stages, genome-wide identification of transcription factor binding sites, and high-resolution maps of chromatin organization. Both studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized. Overall, the studies provide insights into the organization, structure, and function of the two genomes and provide basic information needed to guide and correlate both focused and genome-wide studies.