Published in

Wiley Open Access, Brain and Behavior, 2(4), p. 298-311, 2014

DOI: 10.1002/brb3.205



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Genome-wide polygenic scoring for a 14-year long-term average depression phenotype

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO


BackgroundDespite moderate heritability estimates for depression-related phenotypes, few robust genetic predictors have been identified. Potential explanations for this discrepancy include the use of phenotypic measures taken from a single time point, rather than integrating information over longer time periods via multiple assessments, and the possibility that genetic risk is shaped by multiple loci with small effects.