Published in
Wiley Open Access, Brain and Behavior, 2(4), p. 298-311, 2014
DOI: 10.1002/brb3.205
Links
- ORCID
- ORCID
- Wiley Open Access | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [dash.harvard.edu] | PDF
- [europepmc.org] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Genome-wide polygenic scoring for a 14-year long-term average depression phenotype
Journal article published in 2014 by
Shun-Chiao Chang,
M. Maria Glymour,
M. Maria Glymour,
Stefan Walter 
,
Liming Liang,
Karestan C. Koenen ,
Eric J. Tchetgen,
Marilyn C. Cornelis,
Ichiro Kawachi,
Eric Rimm,
Laura D. Kubzansky
,
Liming Liang,
Karestan C. Koenen ,
Eric J. Tchetgen,
Marilyn C. Cornelis,
Ichiro Kawachi,
Eric Rimm,
Laura D. Kubzansky
This paper is made freely available by the publisher.
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Abstract
BackgroundDespite moderate heritability estimates for depression-related phenotypes, few robust genetic predictors have been identified. Potential explanations for this discrepancy include the use of phenotypic measures taken from a single time point, rather than integrating information over longer time periods via multiple assessments, and the possibility that genetic risk is shaped by multiple loci with small effects.