Published in
Public Library of Science, PLoS ONE, 3(8), p. e59526, 2013
DOI: 10.1371/journal.pone.0059526
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Tools
Diagnosing and Mapping Pulmonary Emphysema on X-Ray Projection Images: Incremental Value of Grating-Based X-Ray Dark-Field Imaging
,
Felix Schwab,
Simone Schleede,
Martin Bech,
Julia Herzen ,
Klaus Achterhold,
Sigrid Auweter,
Fabian Bamberg,
Ali Ö. Yildirim,
Alexander Bohla,
Oliver Eickelberg,
Rod Loewen,
Martin Gifford,
Ronald Ruth,
Maximilian F. Reiser
and other authors.
Full text: Download
Abstract
Purpose: To assess whether grating-based X-ray dark-field imaging can increase the sensitivity of X-ray projection images in the diagnosis of pulmonary emphysema and allow for a more accurate assessment of emphysema distribution. Materials and Methods: Lungs from three mice with pulmonary emphysema and three healthy mice were imaged ex vivo using a laser-driven compact synchrotron X-ray source. Median signal intensities of transmission (T), dark-field (V) and a combined parameter (normalized scatter) were compared between emphysema and control group. To determine the diagnostic value of each parameter in differentiating between healthy and emphysematous lung tissue, a receiver-operating-characteristic (ROC) curve analysis was performed both on a per-pixel and a per-individual basis. Parametric maps of emphysema distribution were generated using transmission, dark-field and normalized scatter signal and correlated with histopathology. Results: Transmission values relative to water were higher for emphysematous lungs than for control lungs (1.11 vs. 1.06, p