Published in
MDPI, International Journal of Molecular Sciences, 7(14), p. 13391-13402, 2013
Links
- ORCID
- ORCID
- MDPI
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.mdpi.com] | PDF
- [dspace.lib.vutbr.cz] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
,
Maja Stanisavljevic,
Marketa Vaculovicova,
Marie Stiborova,
Tomas Eckschlager,
Rene Kizek,
Vojtech Adam
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Abstract
Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.