Aggregation of α-synuclein has been implicated in Parkinson's disease (PD). While quite a few compounds are known to inhibit α-synuclein aggregation, however, dissolution of aggregates into their constituent monomers cannot be readily achieved. In this study, using a range of techniques, we have shown that an optimized cocktail of curcumin and β-cyclodextrin, at appreciably low concentrations, not only inhibited aggregation but also broke up the pre-formed aggregates almost completely. We propose that these compounds exhibit synergy in their action and thus provide us with the exciting prospect of working towards the development of a suitable drug candidate for prevention and treatment of PD.