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Electroanalytical determination of catechin flavonoid in ethyl acetate extracts of medicinal plants

This paper is available in a repository.
This paper is available in a repository.

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Abstract

South African Carpobrotus species have been found to contain hydrolyzable tannins, various flavonoids e.g. rutin and hyperoside, phytosterols and aromatic acids which have a diverse range of pharmacological properties; including antimicrobial and antioxidant activities. In this paper we described the identification and quantification of catechin in C. mellei and C. quadrifidus using cyclic and square wave voltammetry. The oxidation potential of catechin ranges from +171.0 mV to +631.6 mV. The oxidation mechanism proceeds in sequential steps, related to the catechol moiety and 3-hydroxyl group. The oxidation of the catechol electron donating group occurs first at low potential and is a reversible reaction. The 3-hydroxyl group oxidises after and undergoes an irreversible reaction. The limit of detection (LOD) of catechin is 0.84 ppm and limit of quantification (LOQ) is 2.79 ppm with R.S.D. equal to 2.5%. The oxidation potentials of the ethyl acetate extracts of C. mellei and C. quadrifidus correspond with that of catechin. The content of catechin in C. mellei and C. quadrifidus was 5.0 ppm and 4.7 ppm, respectively. Other analytical techniques such as HPLC, UV-VIS, NMR, and FTIR were also used to validate the presence of catechin in the plant extracts.