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Oxford University Press (OUP), Rheumatology, 9(54), p. 1549-1556

DOI: 10.1093/rheumatology/kev218

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Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis: Fig. 1

Journal article published in 2015 by Tony J. Kenna, Philip C. Robinson, Nigil Haroon ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

There has been significant progress in our understanding of the pathogenesis of AS. The advent of genome-wide association studies has increased the known loci associated with AS to more than 40. The endoplasmic reticulum resident aminopeptidases (ERAP) 1 and 2 were identified in this manner and are of particular interest. There appears to be a genetic as well as a functional interaction of ERAP1 and 2 with HLA-B27 based on the known functions of these molecules. Recent studies on the structure, immunological effects and the peptide-trimming properties of ERAP 1 and 2 have helped to provide insight into their pathogenic potential in AS. In this review, we explore the role of ERAP 1 and 2 in the pathogenesis of AS.