The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins
Journal article published in 2010 by
Angela Casini,
Claudia Temperini,
Chiara Gabbiani 
,
Claudiu T. Supuran,
Luigi Messori
,
Claudiu T. Supuran,
Luigi Messori
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Abstract
Heavy metals rock! The reactivity of the antimetastatic metallodrug NAMI-A with human carbonic anhydrase II (hCAII) has been investigated using a number of techniques, including X-ray crystallography. The characterization of the interactions between NAMI-A and hCAII provides valuable information on the molecular mechanisms responsible for the activity of this promising anticancer agent.