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Nature Research, Nature Genetics, 5(48), p. 552-555, 2016

DOI: 10.1038/ng.3529

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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

Journal article published in 2015 by Elise B. Robinson, Robinson Eb, Beate St Pourcain ORCID, Verneri Anttila ORCID, Kosmicki Ja, Jack A. Kosmicki, Brendan Bulik-Sullivan, Marie Baekvad-Hansen, Jakob Grove ORCID, Richard Belliveau, Julian Maller, Ditte Demontis, Kaitlin E. Samocha ORCID, Stephan J. Sanders ORCID, Samocha Ke and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.