Published in
Sociedade Brasileira de Química, SBQ, Journal of the Brazilian Chemical Society, 2014
DOI: 10.5935/0103-5053.20140062
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- Sociedade Brasileira de Química, SBQ
- ORCID
- ORCID
- [www.scielo.br]
- [www.researchgate.net]
- [www.scielo.br] | PDF
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Synthesis andin vitroEvaluation of New Benzenesulfonamides as Antileishmanial Agents
Journal article published in 2014 by
Julio C. Borges,
Adriana V. Carvalho,
Alice M. R. Bernardino 
,
César D. Oliveira,
Luiz C. S. Pinheiro ,
Roberta K. F. Marra,
Helena C. Castro,
Solange M. S. V. Wardell,
James L. Wardell,
Veronica F. Amaral,
Marilene M. Canto-Cavalheiro,
Leonor L. Leon,
Marcelo Genestra
,
César D. Oliveira,
Luiz C. S. Pinheiro ,
Roberta K. F. Marra,
Helena C. Castro,
Solange M. S. V. Wardell,
James L. Wardell,
Veronica F. Amaral,
Marilene M. Canto-Cavalheiro,
Leonor L. Leon,
Marcelo Genestra
This paper is made freely available by the publisher.
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Abstract
This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.