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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, Acta Cirurgica Brasileira, 4(29), p. 274-279, 2014

DOI: 10.1590/s0102-86502014000400009

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Urethral dysfunction due to alloxan-induced diabetes. Urodynamic evaluation and action of sildenafil citrate

Journal article published in 2014 by Pegorare,Ana Beatriz Gomes de Souza, Ana Beatriz Gomes de Souza Pegorare, Alessandra Martiniano de Oliveira, Ana Beatriz Gomes de Souza Pegorare, Gonçalves,Marco Antonio, Marco Antonio Gonçalves, Oliveira,Alessandra Martiniano De, Alessandra Martiniano de Oliveira, Rodrigues Junior,Antonio Antunes, Antonio Antunes Rodrigues, Tucci Jr,Silvio, Silvio Tucci ORCID, Suaid,Haylton Jorge, Haylton Jorge Suaid
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

PURPOSE: To evaluate the effect of diabetes mellitus and of sildenafil citrate on female urethral function.METHODS: Twenty nine female rats were divided into four groups: G1 - (n=9), normal rats; G2 - (n=6), normal rats treated with sildenafil citrate; G3 - (n=9) rats with alloxan-induced diabetes; G4 - (n=5) rats with alloxan-induced diabetes treated with sildenafil citrate. Under anesthesia, urodynamic evaluation was performed by cystometry and urethral pressure simultaneously.RESULTS: A significant increase in urethral pressure was observed during micturition.CONCLUSION: Sildenafil citrate can partially reduced urethral pressure in diabetic female rats.