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Sociedade Brasileira de Química, Química Nova, 4(36), p. 495-501

DOI: 10.1590/s0100-40422013000400002

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Síntese, caracterização e estudo das propriedades de um novo complexo mononuclear contendo quercetina e íon Ga(III)

Journal article published in 2013 by Simões,Vanessa do Nascimento, Tamires Donizeth de Oliveira ORCID, Favarin,Lis Regiane Vizolli, Vanessa do Nascimento Simões, Lis Regiane Vizolli Favarin, Cabeza,Natália Aparecida, Natália Aparecida Cabeza, Tamires Donizeth de Oliveira, Oliveira,Tamires Donizeth De, Fiorucci,Antonio Rogério, Antonio Rogério Fiorucci, Stropa,Jusinei Meireles, Jusinei Meireles Stropa, Rodrigues,Daniela Cristina Manfroi, Daniela Cristina Manfroi Rodrigues and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Flavonoids are one of the most important compound groups applied as medicine given their antioxidant properties, but several intrinsic properties can be improved through structural modifications to their molecules. Here, the synthesis and characterization of a new gallium (III) complex with quercetin is described. Electrochemical properties, as well as antioxidant and cytotoxic activities, were investigated and compared to the free flavonoid molecule. The mononuclear complex obtained, [Ga(C15H9O7)3].2H2O.2CH3OH.CH3CH2OH, seems more active as a DPPH radical scavenger given its lower oxidation potential compared to quercetin. The new complex cytotoxic responses have shown to be more effective than those of the free flavonoid and of lapachol used as a control.