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Sociedade Brasileira de Química, Química Nova, 4(33), p. 968-971

DOI: 10.1590/s0100-40422010000400037

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Development and validation of UV spectrophotometric method for determination of levofloxacin in pharmaceutical dosage forms

Journal article published in 2010 by Nájla Mohamad Kassab ORCID, Kassab,Nájla Mohamad, Marcos Serrou do Amaral, Amaral,Marcos Serrou Do, Anil Kumar Singh, Singh,Anil Kumar, Maria Inês Rocha Miritello Santoro, Santoro,Maria Inês Rocha Miritello
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The objective of this research was to develop and validate an alternative analytical method for quantitative determination of levofloxacin in tablets and injection preparations. The calibration curves were linear over a concentration range from 3.0 to 8.0 μg mL-1. The relative standard deviation was below 1.0% for both formulations and average recovery was 101.42 ± 0.45% and 100.34 ± 0.85% for tablets and injection formulations, respectively. The limit of detection and limit of quantitation were 0.08 and 0.25 μg mL-1, respectively. It was concluded that the developed method is suitable for the quality control of levofloxacin in pharmaceuticals formulations.