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Conselho Brasileiro de Oftalmologia, Arquivos Brasileiros de Oftalmologia, 6(72), p. 793-798

DOI: 10.1590/s0004-27492009000600010

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Evaluation of early abnormalities of the sensory retina in a hypercholesterolemia experimental model: an immunohistochemical study

Journal article published in 2009 by Torres,Rogil José de Almeida, Rogil José de Almeida Torres, Greyce Kelly de Souza, Rogil José de Almeida Torres, Maurício Maia, Maia,Maurício, Précoma,Dalton Bertolin, Dalton Bertolin Précoma, Lucia Noronha ORCID, Noronha,Lucia, Andréa Luchini, Luchini,Andréa, Précoma,Leonardo Brandão, Leonardo Brandão Précoma, Souza,Greyce Kelly De and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

PURPOSE: The aim of this study is to demonstrate the early changes of the sensory retina induced by hypercholesterolemia in an experimental model. METHODS: New Zealand rabbits were divided into two groups: CG (Control Group) was fed a normal diet for 6 weeks. G1 was initially fed a 1% cholesterol diet for two weeks and from the 14th day on a 0.5% cholesterol diet until the 42nd day. The eyes underwent an immunohistochemical analysis with monoclonal antibodies anti-calretinin and anti-glial fibrillary acidic protein (GFAP). RESULTS: G1 cells and cell elements presented significant immunoreactivity to anti-calretinin. No immunoreactivity to anti-glial fibrillary acidic protein was observed in both groups. CONCLUSION: This study has shown that a hypercholesterolemic diet may induce early changes in the sensory retina in rabbits. The anti-calretinin monoclonal antibody was able to reveal calcium accumulation inside the nerve cells.