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Public Library of Science, PLoS ONE, 9(10), p. e0135515, 2015

DOI: 10.1371/journal.pone.0135515

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Macrophage bactericidal activities against Staphylococcus aureus are enhanced in vivo by selenium supplementation in a dose-dependent manner

Journal article published in 2015 by Mourad Aribi ORCID, Warda Meziane, Salim Habi, Yasser Boulatika, Hélène Marchandin, Jean-Luc Aymeric
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dietary selenium is of fundamental importance to maintain optimal immune function and enhance immunity during infection. To this end, we examined the effect of selenium on macrophage bactericidal activities against Staphylococcus aureus. Assays were performed in golden Syrian hamsters and peritoneal macrophages cultured with S. aureus and different concentrations of selenium. Infected and selenium-supplemented animals have significantly decreased levels of serum nitric oxide (NO) production when compared with infected but non-selenium-supplemented animals at day 7 post-infection (p