Published in
BioMed Central, Malaria Journal, 1(14), 2015
DOI: 10.1186/s12936-015-0939-1
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- [spiral.imperial.ac.uk] | PDF
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Tools
Serology describes a profile of declining malaria transmission in Farafenni, The Gambia
,
Muna Affara,
Stephen J. Allen,
Carla Proietti,
Serign J. Ceesay,
Geoffrey A. Targett,
Umberto D'Alessandro,
Umberto D’Alessandro
and other authors.
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Abstract
Abstract Background Malaria morbidity and mortality has declined in recent years in a number of settings. The ability to describe changes in malaria transmission associated with these declines is important in terms of assessing the potential effects of control interventions, and for monitoring and evaluation purposes. Methods Data from five cross-sectional surveys conducted in Farafenni and surrounding villages on the north bank of River Gambia between 1988 and 2011 were compiled. Antibody responses to MSP-1 19 were measured in samples from all surveys, data were normalized and expressed as seroprevalence and seroconversion rates (SCR) using different mathematical models. Results Results showed declines in serological metrics with seroprevalence in children aged one to 5 years dropping from 19 % (95 % CI 15–23 %) in 1988 to 1 % (0–2 %) in 2011 ( p value for trend in proportions