Dissemin is shutting down on January 1st, 2025

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Wiley Open Access, Journal of the American Heart Association, 8(4), 2015

DOI: 10.1161/jaha.115.001853

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Sex‐Specific Effects of Adiponectin on Carotid Intima‐Media Thickness and Incident Cardiovascular Disease

Journal article published in 2015 by Jonas Persson, Rona J. Strawbridge ORCID, Olga McLeod, Strawbridge Rj, Karl Gertow, Angela Silveira ORCID, Damiano Baldassarre, Natalie Van Zuydam, Sonia Shah, Cristiano Fava, Stefan Gustafsson, Maria Sabater‐Lleal, Fabrizio Veglia, Bengt Sennblad, Ulf de Faire and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background Plasma adiponectin levels have previously been inversely associated with carotid intima‐media thickness ( IMT ), a marker of subclinical atherosclerosis. In this study, we used a sex‐stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT . Methods and Results Baseline plasma adiponectin concentration was tested for association with baseline IMT , IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (β=−0.018, P <0.001) in men but not in women (β=−0.006, P =0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (β=−0.0022, P =0.047), whereas no association was seen in women (0.0007, P =0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82, 95% CI 0.54 to 1.25). A gene score of adiponectin‐raising alleles in 6 loci, reported recently in a large multi‐ethnic meta‐analysis, was inversely associated with baseline mean bifurcation IMT in men (β=−0.0008, P =0.004) but not in women (β=−0.0003, P =0.522; P for interaction=0.007). Conclusions This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.