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BioMed Central, Arthritis Research and Therapy, 4(9), p. 219

DOI: 10.1186/ar2200

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Cells of the synovium in rheumatoid arthritis. Dendritic cells

Journal article published in 2007 by Viviana Lutzky, Suad Hannawi ORCID, Suad Suad Hannawi, Ranjeny Thomas
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB.