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eLife Sciences Publications, eLife, (4), 2015

DOI: 10.7554/elife.10206

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Cell type-specific pharmacology of NMDA receptors using masked MK801

Journal article published in 2015 by Yunlei Yang, Peter Lee ORCID, Scott M. Sternson ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons are necessary for cocaine-induced synaptic potentiation, demonstrating that cell type-specific pharmacology can be used to dissect signaling pathways within complex brain circuits.