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Frontiers Media, Frontiers in Pediatrics, (3), 2015

DOI: 10.3389/fped.2015.00078

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The Evidence-Based Approach to Adult-Onset Idiopathic Nephrotic Syndrome

Journal article published in 2015 by Pietro A. A. Canetta ORCID, Jai Radhakrishnan
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Adult-onset nephrotic syndrome (NS) differs from its pediatric counterpart in several important ways. Most importantly, NS in adults is more etiologically heterogeneous compared to children, and thus treatment approaches rely heavily on the histological diagnosis provided by renal biopsy. The evidence-based approach to treatment of adult NS has been critically examined by the Kidney Disease Improving Global Outcomes (KDIGO) guidelines in glomerulonephritis, published in 2012. Here, we examine the strengths and limits of those guidelines and review recent work that expands the evidence-based approach.