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Frontiers Media, Frontiers in Genetics, (6), 2015

DOI: 10.3389/fgene.2015.00278

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Polymorphisms in Toll-like receptor genes are associated with vitiligo

Journal article published in 2015 by Maire Karelson, Maris Keermann, Tanel Traks, Ene Reimann ORCID, Ranno Rätsep ORCID, Helgi Silm, Külli Kingo, Sulev Kõks ORCID, Eero Vasar
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: The members of Toll-like receptor (TLR) family are responsible for recognizing various molecular patterns associated with pathogens. Their expression is not confined to immune cells and have been detected in skin cells such as keratinocytes and melanocytes. As part of a generated response to pathogens, TLRs are involved in inducing inflammatory mediators to combat these threats. It is therefore not surprising that TLRs have been implicated in inflammatory skin diseases, including atopic dermatitis and psoriasis. Likewise, as key players in autoimmunity, they have been associated with a number of autoimmune diseases. Based on this, the role of TLRs in vitiligo could be suspected, but is yet to be clearly established.