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Frontiers Media, Frontiers in Immunology, (6)

DOI: 10.3389/fimmu.2015.00462

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Transcriptional Enhancers in the Regulation of T Cell Differentiation

Journal article published in 2015 by Michelle L. T. Nguyen, Sarah A. Jones ORCID, Julia E. Prier, Brendan E. Russ
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The changes in phenotype and function that characterize the differentiation of naïve T cells to effector and memory states are underscored by large-scale, coordinated, and stable changes in gene expression. In turn, these changes are choreographed by the interplay between transcription factors and epigenetic regulators that act to restructure the genome, ultimately ensuring lineage-appropriate gene expression. Here, we focus on the mechanisms that control T cell differentiation, with a particular focus on the role of regulatory elements encoded within the genome, known as transcriptional enhancers (TEs). We discuss the central role of TEs in regulating T cell differentiation, both in health and disease.