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American Chemical Society, Biomacromolecules, 7(10), p. 2009-2012, 2009

DOI: 10.1021/bm900263z

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Biodefunctionalization of Functionalized Single-Walled Carbon Nanotubes in Mice

Journal article published in 2009 by Sheng-Tao Yang ORCID, Haifang Wang, Mohammed J. Meziani, Yuanfang Liu, Xin Wang, Ya-Ping Sun
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Chemically modified carbon nanotubes with hydrophilic functionalities such as polyethylene glycols (PEGs) are widely pursued for potential biological and biomedical applications. In this study, PEGylated single-walled carbon nanotubes (PEG-SWNT) were intravenously administrated into mice to study their bio-defunctionalization in vivo by using complementary Raman and photoluminescence measurements. There was meaningful defunctionalization of PEG-SWNT in liver over time, but not in spleen under similar conditions. The evidence from spectroscopic characterization and analyses is presented, and mechanistic implications are discussed.