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BMJ Publishing Group, Thorax, 7(70), p. 617-624, 2015

DOI: 10.1136/thoraxjnl-2014-206680

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Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

Journal article published in 2015 by Rca C. A. Dancer, Dhruv Parekh, Sian Lax, Vijay D'Souza, Shengxing Zheng, Cr R. Bassford, Daniel Park, Dg G. Bartis, Rahul Mahida, Am M. Turner ORCID, Elizabeth Sapey, Wenbin Wei, Babu Naidu, Pm M. Stewart, Wd D. Fraser and other authors.
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Abstract

Rationale: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never been demonstrated. Objectives: To determine if ARDS is associated with vitamin D deficiency in a clinical setting and to determine if vitamin D deficiency in experimental models of ARDS influences its severity. Methods: Human, murine and in vitro primary alveolar epithelial cell work were included in this study. Findings: Vitamin D deficiency (plasma 25(OH)D levels 600 genes. In a clinical setting, pharmacological repletion of vitamin D prior to oesophagectomy reduced the observed changes of in vivo measurements of alveolar capillary damage seen in deficient patients. Conclusions: Vitamin D deficiency is common in people who develop ARDS. This deficiency of vitamin D appears to contribute to the development of the condition, and approaches to correct vitamin D deficiency in patients at risk of ARDS should be developed.