Wiley, Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 4S_Part_10(7), 2011
DOI: 10.1016/j.jalz.2011.05.996
Wiley, Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 4S_Part_1(7), 2011
DOI: 10.1016/j.jalz.2011.05.040
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The hippocampus presents the highest rate of atrophy in the early stage of Alzheimer's disease (AD), with more pronounced neuron loss reported in CA1 and subiculum. The aim of this study is to increase the discrimination power of hippocampal shape analysis between AD and normal controls (NC) by focusing on the subregions with atrophy associated with AD and describing the localized shape changes using statistical shape models (SSMs).