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Elsevier, Bioorganic and Medicinal Chemistry, 1(21), p. 153-165

DOI: 10.1016/j.bmc.2012.10.042

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Carbohydrate-conjugated porphyrin dimers: synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy.

Journal article published in 2013 by Guillaume Garcia, Fabien Hammerer, Florent Poyer, Sylvain Achelle, Marie-Paule Teulade-Fichou, Philippe Maillard
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

We report the synthesis of bioconjugated zinc porphyrin dimers 1a-e designed as photosensitizers for one-photon and two-photon excited photodynamic therapy. These macrocycles are substituted with carbohydrate units (glucose, mannose, lactose) in order to target tumor cells over-expressing lectin membrane receptors. Polarity, singlet oxygen production and in vitro photocytotoxicity are studied to determine their photodynamic therapy potentiality.