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Wiley, European Journal of Organic Chemistry, 7(2011), p. 1271-1279, 2011

DOI: 10.1002/ejoc.201001209

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Carbohydrate-Porphyrin Conjugates with Two-Photon Absorption Properties as Potential Photosensitizing Agents for Photodynamic Therapy

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

We report the synthesis of a series of conjugated zinc porphyrin oligomers designed as photodynamic therapy agents. These compounds exhibit exceptionally high two-photon absorption cross-sections, redshifted linear absorption spectra, and high singlet oxygen quantum yields, making them ideal for one-photon- and two-photon-excited photodynamic therapy. These products are substituted by three α-mannose units on each chromophore with the aim to target tumor cells with over-expressing lectin-type membrane receptors.