In this paper we present two case studies of electronic embedded systems for biomedical applications: ENDOCOM and CYCLOPE. In the former, we designed and realized the prototype of an implantable pressure sensor for the follow-up of the abdominal aortic aneurysm treated by a stent. Numerical modeling, in vitro experiments and in vivo tests on large animal model demonstrated the successful real-time follow-up of the pressure in the aneurysm sac. In the latter, we designed an embedded active multispectral vision system for the real time detection of polyps based both on the classification of the 3D reconstruction of the polyps by SVM and the classification of the texture by boosting methods. An FPGA-based demonstrator of the system was realized. Experiments in laboratory, in vitro and in vivo on a pig were performed to obtain its performances. This system could be integrated into a wireless capsule for colorectal endoscopy. © Institute for Computer Sciences, Social Informatics and Telecommunications Engineering 2013.