The degradation of concrete structures caused by delayed ettringite formation (DEF) is a problem that affects many concrete structures worldwide [1]. This pathology is due to the formation of expansive ettringite inside the material and is very difficult to deal with, because presently there is no efficient method to repair concrete structures affected by DEF. Hence, there is an urgent need to find preventive methods that may enable the inhibition of DEF in new constructions. This paper presents the findings of a long-term study [2,3] on the expansion rate and microstructure of heat-cured concretes with different amounts of mineral additions available in Portugal, like fly ash, metakaolin, ground granulated blast-furnace slag, silica fume and limestone filler. For this purpose different concrete compositions were produced using the same binder, water/cement (w/c)ratios and aggregate type. The concretes were prepared and subjected to a heat-curing cycle based on a temperature core rise obtained during setting of a massive cast-in-place concrete with 14 m length, 3,5 m width and 1,5 m high. Following the heat-curing cycle, the concrete specimens were demolded and subsequently subjected to two drying-humidification cycles. After these cycles the concrete specimens were immersed in water for long-term storage at 20 ± 2ºC. Length changes of specimens were measured at regular intervals. The microstructures of old heat curing specimens were investigated by optical microscopy using polarised and fluorescence light and SEM-EDS analysis. The results of the blended-concrete compositions were compared with control compositions, and the conclusions were extracted.