Published in
Elsevier, Microbes and Infection, 5(9), p. 623-628
DOI: 10.1016/j.micinf.2007.02.002
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Tumor necrosis factor is critical to control tuberculosis infection.
Journal article published in 2007 by
Muazzam Jacobs,
Dieudonnée Togbe 
,
Cecile Fremond,
Arina Samarina,
Nasiema Allie,
Tania Botha,
Daniela Carlos,
Shreemanta K. Parida,
Sergei Grivennikov,
Sergei Nedospasov,
Analbery Monteiro,
Marc Le Bert,
Marc Le Bert,
Valerie Quesniaux,
Bernhard Ryffel
,
Cecile Fremond,
Arina Samarina,
Nasiema Allie,
Tania Botha,
Daniela Carlos,
Shreemanta K. Parida,
Sergei Grivennikov,
Sergei Nedospasov,
Analbery Monteiro,
Marc Le Bert,
Marc Le Bert,
Valerie Quesniaux,
Bernhard Ryffel
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Abstract
Tumor necrosis factor (TNF) is critical and non-redundant to control Mycobacterium tuberculosis infection and cannot be replaced by other proinflammatory cytokines. Overproduction of TNF may cause immunopathology, while TNF neutralization reactivates latent and chronic, controlled infection, which is relevant for the use of neutralizing TNF therapies in patients with rheumatoid arthritis.