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eLife Sciences Publications, eLife, (4), 2015

DOI: 10.7554/elife.05357

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Dynamic subcellular localization of a respiratory complex controls bacterial respiration

Journal article published in 2015 by François Alberge, Leon Espinosa, Farida Seduk, Léa Sylvi, René Toci, Axel Magalon ORCID, Anne Walburger
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Respiration, an essential process for most organisms, has to optimally respond to changes in the metabolic demand or the environmental conditions. The branched character of their respiratory chains allows bacteria to do so by providing a great metabolic and regulatory flexibility. Here, we show that the native localization of the nitrate reductase, a major respiratory complex under anaerobiosis in Escherichia coli, is submitted to tight spatiotemporal regulation in response to metabolic conditions via a mechanism using the transmembrane proton gradient as a cue for polar localization. These dynamics are critical for controlling the activity of nitrate reductase, as the formation of polar assemblies potentiates the electron flux through the complex. Thus, dynamic subcellular localization emerges as a critical factor in the control of respiration in bacteria.