Published in

Cell Press, Cell Reports, 9(11), p. 1446-1457, 2015

DOI: 10.1016/j.celrep.2015.04.063

Links

Tools

Export citation

Search in Google Scholar

Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia

Journal article published in 2015 by Pierre Sujobert, Laury Poulain, Etienne Paubelle, Florence Zylbersztejn, Adrien Grenier, Mireille Lambert, Elizabeth C. Townsend, Jean-Marie Brusq, Edwige Nicodeme, Justine Decrooqc, Ina Nepstad, Alexa S. Green, Johanna Mondesir, Marie-Anne Hospital, Nathalie Jacque and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Graphical Abstract Highlights d AMPK activation blocks AML propagation without toxicity to normal hematopoiesis d Cytotoxicity induced by an AMPK activator (GSK621) involves autophagy in AML d Co-activation of AMPK and mTORC1 is synthetically lethal in AML d AMPK and mTORC1 crosstalk requires eIF2a/ATF4 signaling