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Elsevier, European Journal of Cancer, 7(45), p. 1175-1183, 2009

DOI: 10.1016/j.ejca.2008.11.039

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The abdominoperineal resection itself is associated with an adverse outcome: the European experience based on a pooled analysis of five European randomised clinical trials on rectal cancer.

Journal article published in 2009 by Marcel Den Dulk, Hein Putter, Laurence Collette, Corrie A. M. Marijnen ORCID, Joakim Folkesson, Jean-Francois Bosset, Claus Rödel, Krzysztof Bujko, Cornelis J. H. van de Velde, Lars Påhlman
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

PURPOSE: The aim of this study is to identify factors associated with the decision to perform an abdominoperineal resection (APR) and to assess if these factors or the surgical procedure itself is associated with circumferential resection margin (CRM) involvement, local recurrence (LR), overall survival (OS) and cancer-specific survival (CSS). PATIENTS AND METHODS: The Swedish Rectal Cancer Trial (SRCT), TME trial, CAO/ARO/AIO-94 trial, EORTC 22921 trial and Polish Rectal Cancer Trial (PRCT) were pooled. A propensity score was calculated, which indicated the predicted probability of undergoing an APR given gender, age and distance, and used in the multivariate analyses. RESULTS: An APR procedure was associated with an increased risk of CRM involvement [odd ratio (OR) 2.52, p