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Oxford University Press, International Journal of Epidemiology, 4(44), p. 1211-1223, 2015

DOI: 10.1093/ije/dyv043

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Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome

Journal article published in 2015 by Elmar W. Tobi, Roderick C. Slieker, Aryeh D. Stein, H. Eka D. Suchiman, H. Eka D. Suchiman ORCID, P. Eline Slagboom, P. Eline Slagboom ORCID, Erik W. van Zwet, Bastiaan T. Heijmans, Lh H. Lumey
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: The manipulation of pregnancy diets in animals can lead to changes in DNA methylation with phenotypic consequences in the offspring. Human studies have concentrated on the effects of nutrition during early gestation. Lacking in humans is an epigenome-wide association study of DNA methylation in relation to perturbations in nutrition across all gestation periods.