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American Society for Cell Biology, Molecular Biology of the Cell, 13(26), p. 2550-2560

DOI: 10.1091/mbc.e14-05-1002

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Proliferation-dependent positioning of individual centromeres in the interphase nucleus of human lymphoblastoid cell lines

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Centromeres are not randomly distributed in interphase nuclei. High-throughput imaging provides an accurate characterization of how their organization varies as a function of the proliferation state in human lymphoblastoid cells. The results suggest the existence of mechanisms that drive the nuclear positioning of centromeres.