Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Structural and Molecular Biology, 4(22), p. 345-347, 2015

DOI: 10.1038/nsmb.2996

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Structural organization of the dynein-dynactin complex bound to microtubules

Journal article published in 2015 by Saikat Chowdhury ORCID, Stephanie A. Ketcham, Trina A. Schroer, Gabriel C. Lander
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin, and the dynein-dynactin-microtubule quaternary complex. In the microtubule-bound complex, the dynein motor domains are positioned for processive unidirectional movement and the cargo binding domains of both dynein and dynactin are accessible.