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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 4(59), p. 2421-2425, 2015

DOI: 10.1128/aac.03926-14

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Dissemination of High-Risk Clones of Extensively Drug-Resistant Pseudomonas aeruginosa in Colombia

Journal article published in 2015 by Adriana Correa, Rosa del Campo ORCID, Marcela Perenguez, Victor M. Blanco, Mercedes Rodríguez-Baños, Federico Perez, Juan J. Maya, Laura Rojas, Rafael Cantón, Cesar A. Arias, Maria V. Villegas
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains. These lineages belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor bla VIM-2 on a class 1 integron and bla KPC-2 on a Tn 4401 transposon, respectively. Additionally, P. aeruginosa ST1492, a novel single-locus variant of ST111, was identified. Clonal dissemination and the presence of mobile genetic elements likely explain the successful spread of XDR P. aeruginosa strains in Colombia.