Published in
Oxford University Press (OUP), Neuro-Oncology, suppl 6(16), p. vi11-vi11
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- [www.researchgate.net]
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- [www.ncbi.nlm.nih.gov] | PDF
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P67defining a Target Intra-Cerebrospinal Fluid Steady State Etoposide Concentration [Csf Etoposide] for Phase I Study in Children With Leptomeningeal Metastasis (Lm): Intrepid, a First in Man Study
Journal article published in 2014 by
Lisethe Meijer,
David Walker,
Richard Grundy,
Wojchiech Konczalik,
Delyan Ivanov,
Gareth Veal 
,
Martin Garnett,
Pamela Kearns
,
Martin Garnett,
Pamela Kearns
This paper is made freely available by the publisher.
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Abstract
INTRODUCTION: Continuous intra-CSF etoposide infusion may optimise etoposide pharmacokinetics by bypassing the blood-brain-barrier and compensating for CSF bulk flow removal, at