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Elsevier, Molecular and Cellular Proteomics, 10(13), p. 2584-2592, 2014

DOI: 10.1074/mcp.m114.040113

Wiley, Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 4S_Part_9(10), 2014

DOI: 10.1016/j.jalz.2014.05.393

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Targeting Synaptic Pathology with a Novel Affinity Mass Spectrometry Approach*

Journal article published in 2014 by Ann Brinkmalm, Gunnar Brinkmalm ORCID, William G. Honer, Honer Wg, Julie A. Moreno, Moreno Ja, Joel Jakobsson, Giovanna R. Mallucci ORCID, Mallucci Gr, Henrik Zetterberg, Kaj Blennow, Annika Öhrfelt, A. Ohrfelt
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We report a novel strategy for studying synaptic pathology by concurrently measuring levels of four SNARE complex proteins from individual brain tissue samples. This method combines affinity purification and mass spectrometry and can be applied directly for studies of SNARE complex proteins in multiple species or modified to target other key elements in neuronal function. We use the technique to demonstrate altered levels of presynaptic proteins in Alzheimer disease patients and prion-infected mice.