Oxford University Press (OUP), Brain, 10(137), p. 2670-2679
DOI: 10.1093/brain/awu210
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GNE myopathy is an adult-onset muscle disease caused by genetic defects in sialic acid biosynthesis. In a mouse model of the disorder, Yonekawa et al. reveal that sialic acid supplementation reduces muscle atrophy in aged symptomatic animals. The sialic acid glycoconjugate 6'-sialyllactose has greater therapeutic efficacy than free sialic acid.