Published in
Oxford University Press (OUP), Brain, 10(137), p. 2670-2679
DOI: 10.1093/brain/awu210
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Sialyllactose ameliorates myopathic phenotypes in symptomatic GNE myopathy model mice
Journal article published in 2014 by
Takahiro Yonekawa,
May Christine V. Malicdan,
Anna Cho,
Yukiko K. Hayashi,
Ikuya Nonaka,
Toshiki Mine,
Takeshi Yamamoto 
,
Ichizo Nishino ,
Satoru Noguchi
,
Ichizo Nishino ,
Satoru Noguchi
This paper is made freely available by the publisher.
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Abstract
GNE myopathy is an adult-onset muscle disease caused by genetic defects in sialic acid biosynthesis. In a mouse model of the disorder, Yonekawa et al. reveal that sialic acid supplementation reduces muscle atrophy in aged symptomatic animals. The sialic acid glycoconjugate 6'-sialyllactose has greater therapeutic efficacy than free sialic acid.