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Taylor and Francis Group, Cancer Biology & Therapy, 10(15), p. 1296-1298

DOI: 10.4161/cbt.29926

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Potential novel role of bevacizumab in glioblastoma and cervical cancer

Journal article published in 2014 by Andrew K. L. Goey ORCID, William D. Figg
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The VEGF-A binding monoclonal antibody bevacizumab is a widely prescribed angiogenesis inhibitor and indicated for many types of cancer. As shown by three randomized phase 3 trials recently published in the New England Journal of Medicine, novel indications for this drug are still being explored. In the RTOG 0825 and AVAglio trials the effect of bevacizumab addition to standard therapy in newly diagnosed glioblastoma (radiotherapy plus temozolomide) was investigated, while in GOG 240 the combination of platinum-based chemotherapy plus bevacizumab was explored in advanced cervical cancer.