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Public Library of Science, PLoS ONE, 11(8), p. e81550, 2013

DOI: 10.1371/journal.pone.0081550

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The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression

Journal article published in 2013 by Bernadette Crescenzo-Chaigne, Cyril Barbezange ORCID, Sylvie Van Der Werf
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover, the transcription level of the modified segment seemed to be directly affected by the distal panhandle strength. Citation: Crescenzo-Chaigne B, Barbezange C, van der Werf S (2013) The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression. PLoS ONE 8(11): e81550.