We present new regional petrologic, geochemical, Sr-Nd isotopic, and U-Pb geochronological data on the Turonian-Campanian mafic igneous rocks of Central Hispaniola that provide important clues on the development of the Caribbean island-arc. Central Hispaniola is made up of three main tectonic blocks--Jicomé, Jarabacoa and Bonao--that include four broad geochemical groups of Late Cretaceous mafic igneous rocks: group I, tholeiitic to calc-alkaline basalts and andesites; group II, low-Ti high-Mg andesites and basalts; group III, tholeiitic basalts and gabbros/dolerites; and group IV, tholeiitic to transitional and alkalic basalts. These igneous rocks show significant differences in time and space, from arc-like to non-arc-like characteristics, suggesting that they were derived from different mantle sources. We interpret these groups as the record of Caribbean arc-rifting and back-arc basin development in the Late Cretaceous. The> 90 Ma group I volcanic rocks and associated cumulate complexes preserved in the Jicomé and Jarabacoa blocks represent the Albian to Cenomanian Caribbean island-arc material. The arc rift stage magmatism in these blocks took place during the deposition of the Restauración Formation from the Turonian-Coniacian transition (~ 90 Ma) to Santonian/Lower Campanian, particularly in its lower part with extrusion at 90-88 Ma of group II low-Ti, high-Mg andesites/basalts. During this time or slightly afterwards adakitic rhyolites erupted in the Jarabacoa block. Group III tholeiitic lavas represent the initiation of Coniacian-Lower Campanian back-arc spreading. In the Bonao block, this stage is represented by back-arc basin-like basalts, gabbros and dolerite/diorite dykes intruded into the Loma Caribe peridotite, as well as the Peralvillo Sur Formation basalts, capped by tuffs, shales and Campanian cherts. This dismembered ophiolitic stratigraphy indicates that the Bonao block is a fragment of an ensimatic back-arc basin. In the Jicomé and Jarabacoa blocks, the mainly Campanian group IV basalts of the Peña Blanca, Siete Cabezas and Pelona-Pico Duarte Formation, represent the subsequent stage of back-arc spreading and off-axis non-arc-like magmatism, caused by migration of the arc toward the northeast. These basalts have geochemical affinities with the mantle domain influenced by the Caribbean plume, suggesting that mantle was flowing toward the NE, beneath the extended Caribbean island-arc, in response to rollback of the subducting proto-Caribbean slab.