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Springer Nature [academic journals on nature.com], Genes and Immunity, 7(16), p. 470-480, 2015

DOI: 10.1038/gene.2015.28

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Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

Journal article published in 2015 by Fw W. Miller, W. Chen, Tp P. O'Hanlon, Rg G. Cooper, J. Vencovsky, Lg G. Rider, K. Danko, Lr R. Wedderburn, Ie E. Lundberg, Lm M. Pachman, Am M. Reed, S. R. Ytterberg, L. Padyukov ORCID, A. Selva-O'Callaghan, Tr R. Radstake and other authors.
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Abstract

© 2015 Macmillan Publishers Limited All rights reserved.Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of the major myositis phenotypes in a total of 1710 cases, which included 705 adult dermatomyositis, 473 juvenile dermatomyositis, 532 polymyositis and 202 adult dermatomyositis, juvenile dermatomyositis or polymyositis patients with anti-histidyl-tRNA synthetase (anti-Jo-1) autoantibodies, and compared them with 4724 controls. Single-nucleotide polymorphisms showing strong associations (P