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BioMed Central, BMC Pulmonary Medicine, 1(15)

DOI: 10.1186/s12890-015-0101-4

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Prevention of exacerbations in patients with COPD and vitamin D deficiency through vitamin D supplementation (PRECOVID): a study protocol

Journal article published in 2015 by Rachida Rafiq, Floor E. Aleva, Jasmijn A. Schrumpf, Yvonne F. Heijdra, Christian Taube, Johannes Ma Daniels ORCID, Paul Lips, Pierre M. Bet, Pieter S. Hiemstra ORCID, André Jam van der Ven, Martin den Heijer, Heijer M. Den, Martin den Heijer ORCID, Renate T. de Jongh
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Vitamin D is well known for its function in calcium homeostasis and bone mineralisation, but is increasingly studied for its potential immunomodulatory properties. Vitamin D deficiency is a common problem in patients with COPD. Previous studies have not demonstrated a beneficial effect of vitamin D on exacerbation rate in COPD patients. However, subgroup analyses suggested protective effects in vitamin D deficient patients. Our objective is to assess the effect of vitamin D supplementation on exacerbation rate specifically in vitamin D deficient COPD patients. Methods/Design We will perform a randomised, multi-center, double-blind, placebo-controlled intervention study. The study population consists of 240 COPD patients aged 40 years and older with vitamin D deficiency (25-hydroxyvitamin D concentration